Journal article

Aging and a long-term diabetes mellitus increase expression of 1 alpha-hydroxylase and vitamin D receptors in the rat liver

Ana Vuica, Lejla Ferhatovic Hamzic, Katarina Vukojevic, Milka Jeric, Livia Puljak, Ivica Grkovic, Natalija Filipovic



Diabetes mellitus (DM) is a metabolic disorder associated with serious liver complications. As a metabolic chronic disease, DM is very common in the elderly. Recent studies suggest ameliorating effects of vitamin D on metabolic and oxidative stress in the liver tissue in an experimental model of DM. The aim of this study was to investigate the expression of vitamin D receptors (VDRs) and 1α-hydroxylase, the key enzyme for the production of active vitamin D form (calcitriol) in the liver during long-term diabetes mellitus type 1 (DM1) in aging rats. We performed immunohistochemical analysis of liver expression of 1α-hydroxylase and VDRs during aging in long-term streptozotocin-induced DM1. 1α..

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University of Melbourne Researchers


Awarded by Ministry of Science, Education and Sports, Republic of Croatia

Awarded by Croatian Science Foundation

Funding Acknowledgements

The study was funded by the Ministry of Science, Education and Sports, Republic of Croatia grant no. 216-2160528-0067 and the Croatian Science Foundation (HRZZ) grant no. 02.05./28.