Journal article

Measuring time to biochemical failure in the TROG 96.01 trial: when should the clock start ticking?

James W Denham, Allison Steigler, Mahesh Kumar, David S Lamb, David Joseph, Nigel A Spry, Keen-Hun Tai, Chris Atkinson, Sandra Turner, Peter B Greer, Paul S Gleeson, Catherine D'Este

International Journal of Radiation Oncology*Biology*Physics | Published : 2009

Abstract

PURPOSE: We sought to determine whether short-term neoadjuvant androgen deprivation (STAD) duration influences the optimal time point from which Phoenix fail (time to biochemical failure; TTBF) should be measured. METHODS AND MATERIALS: In the Trans-Tasman Radiation Oncology Group 96.01 trial, men with locally advanced prostate cancer were randomized to 3 or 6 months STAD before and during prostatic irradiation (XRT) or to XRT alone. The prognostic value of TTBF measured from the end of radiation (ERT) and randomization were compared using Cox models. RESULTS: Between 1996 and 2000, 802 eligible patients were randomized. In 436 men with Phoenix failure, TTBF measured from randomization was a..

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University of Melbourne Researchers