Quantitative fMRI using hyperoxia calibration: reproducibility during a cognitive Stroop task.
Jonathan A Goodwin, Rishma Vidyasagar, George M Balanos, Daniel Bulte, Laura M Parkes
Neuroimage | Published : 2009
Arterial spin labelling allows simultaneous measurement of both the blood-oxygenation-level-dependent (BOLD) and the cerebral blood flow (CBF) response to changes in neural activity. The addition of a hypercapnia or hyperoxia calibration allows additional quantification of changes in the cerebral metabolic rate of oxygen (CMRO(2)). In this study we test the reproducibility of measurements derived using the hyperoxia approach, during a cognitive Stroop task. A QUIPSSII sequence is used at 3 T to collect simultaneous CBF and BOLD signal during two 3 min periods of hyperoxia and an 8 min Stroop task. Hyperoxia was administered via an open system and end-tidal values were sampled via a nasal can..View full abstract
Awarded by Medical Research Council