Recirculating and Resident Memory CD8( ) T Cells

Abstract

The outer and inner linings of our body in skin and mucosa are under constant threat from pathogens that may cause debilitating infectious disease. Memory T cells that accumulate in these extralymphoid sites provide a critical first line of defense against pathogen invasion and therefore are considered important components of future vaccine strategies. Recent work has emphasized the complex nature of this peripheral T cell compartment, comprising of both recirculating and permanently resident memory cells. In this article, we will summarize current concepts in immune surveillance by recirculating and tissue-resident memory T (TRM) cells and will emphasize the rapidly emerging role of TRM cel..