Journal article

Gene therapy strategies towards immune tolerance to treat the autoimmune diseases

C Siatskas, J Chan, J Field, K Murphy, Z Nasa, BH Toh, F Alderuccio

Current Gene Therapy | BENTHAM SCIENCE PUBL LTD | Published : 2006


Autoimmune diseases such as type 1 diabetes and multiple sclerosis pose a significant health burden on our society. As a whole, autoimmune diseases affect approximately 6% of the population and are the third largest disease burden after heart disease and cancer. Such pathologic manifestations arise by way of damaging reactions of B-cell derived antibodies and/or T-cells to self-antigens and are triggered by genetic and environmental factors. Currently there is no known cure, with treatment restricted to toxic, long-term immunosuppressive regimes, replacement therapy and in intractable cases, transplantation of autologous or allogeneic haematopoietic stem cells. In experimental models of auto..

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University of Melbourne Researchers