White Wine Consumption Influences Inflammatory Phase of Repair After Myocardial Infarction in Rats.
Nikola Ključević, Ana Marija Milat, Mia Grga, Ivana Mudnić, Mladen Boban, Ivica Grković
J Cardiovasc Pharmacol | Published : 2017
Effects of white wine (WW) consumption on the expression of inflammatory markers/mediators (MMP-2, MMP-9, NF-ĸB p65 and TGF-β1) in myocardial tissue after experimentally induced permanent myocardial ischemia was investigated. Male Sprague-Dawley rats were given either a combination of WW and water or only water, for 28 days. After coronary ligation, animals were left to survive for 24 hours. Three representative areas: infarct/ischemic, peri-infarct/border zone, and control/non-ischemic zones were analyzed for expression of immunoreactivity by measuring the threshold area % of signal density. For MMP-9, significantly smaller expression was found in all 3 zones of wine drinking animals (P < 0..View full abstract