Journal article

Characterization of spinal afferent neurons projecting to different chambers of the rat heart.

Maja Marinović Guić, Vana Kosta, Jure Aljinović, Damir Sapunar, Ivica Grković

Neurosci Lett | Published : 2010

Abstract

The pattern of distribution of spinal afferent neurons (among dorsal root ganglia-DRGs) that project to anatomically and functionally different chambers of the rat heart, as well as their morphological and neurochemical characteristics were investigated. Retrograde tracing using a patch loaded with Fast blue (FB) was applied to all four chambers of the rat heart and labeled cardiac spinal afferents were characterized by using three neurochemical markers. The majority of cardiac projecting neurons were found from T1 to T4 DRGs, whereas the peak was at T2 DRG. There was no difference in the total number of FB-labeled neurons located in ipsilateral and contralateral DRGs regardless of the chamb..

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University of Melbourne Researchers