Omega-3 polyunsaturated fatty acid supplementation for improving peripheral nerve health: Protocol for a systematic review

Abstract

Introduction Damage to peripheral nerves occurs in a variety of health conditions. Preserving nerve integrity, to prevent progressive nerve damage, remains a clinical challenge. Omega-3 polyunsaturated fatty acids (PUFAs) are implicated in the development and maintenance of healthy nerves and may be beneficial for promoting peripheral nerve health. The aim of this systematic review is to assess the effects of oral omega-3 PUFA supplementation on peripheral nerve integrity, including both subjective and objective measures of peripheral nerve structure and/or function. Methods and analysis A systematic review of randomised controlled trials that have evaluated the effects of omega-3 PUFA suppl..