Journal article

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

Helen B Pearson, Jason Li, Valerie S Meniel, Christina M Fennell, Paul Waring, Karen G Montgomery, Richard J Rebello, Arthi A Macpherson, Sarah Koushyar, Luc Furic, Carleen Cullinane, Richard W Clarkson, Matthew J Smalley, Kaylene J Simpson, Toby J Phesse, Peter R Shepherd, Patrick O Humbert, Owen J Sansom, Wayne A Phillips

Cancer Discovery | AMER ASSOC CANCER RESEARCH | Published : 2018

Grants

Awarded by Prostate Cancer Foundation of Australia


Awarded by NHMRC


Awarded by Peter MacCallum Cancer Foundation


Awarded by Marie Sklodowska Curie Actions/Ser Cymru II/Horizons 2020 COFUND fellowship


Awarded by Department of Health and Human Services acting through the Victorian Cancer Agency


Awarded by NHMRC Senior Research Fellowship


Funding Acknowledgements

This work was generously supported by a Prostate Cancer Foundation of Australia concept grant (#CG 1611) and an NHMRC project grant (#1080491) awarded to W.A. Phillips, and a Peter MacCallum Cancer Foundation grant (#1520) awarded to H.B. Pearson. H.B. Pearson is supported by a Marie Sklodowska Curie Actions/Ser Cymru II/Horizons 2020 COFUND fellowship (#663830-CU-041). T.J. Phesse is supported by a Capital Medical University/Cardiff University Fellowship. L. Furic is supported by the Department of Health and Human Services acting through the Victorian Cancer Agency (MCRF16007). P.O. Humbert is supported by an NHMRC Senior Research Fellowship (#1079133). The Victorian Centre for Functional Genomics (VCFG) and the RPPA platform (K. J. Simpson) is funded by the Australian Cancer Research Foundation (ACRF), the Australian Phenomics Network (APN) through funding from the Australian Government's National Collaborative Research Infrastructure Strategy (NCRIS) program, the Peter MacCallum Cancer Foundation, and the University of Melbourne Collaborative Research Infrastructure Program. The authors wish to thank the animal, bioinformatics, VCFG-RPPA, microscopy, and histology core facilities at the Peter MacCallum Cancer Centre for supporting this project, and the histology departments at the Beatson Institute of Cancer Research and the European Cancer Stem Cell Research Centre. We also thank Nathan Crouch (VCFG-RPPA) for bioinformatics analysis of RPPA data, as well as Samantha McIntosh, Kerry Ardley, Susan Jackson, Lauren Dawes, Stephanie Le, Katherine Papastratos, and Qerime Mundrea at the Peter MacCallum Cancer Centre, Rachel Ridgway at the Beatson Institute for Cancer Research, and Derek Scarborough at The School of Biosciences, Cardiff University, for their technical assistance.