Journal article

Relaxin Deficiency Leads to Uterine Artery Dysfunction During Pregnancy in Mice

Sarah A Marshall, Sevvandi N Senadheera, Maria Jelinic, Kelly O'Sullivan, Laura J Parry, Marianne Tare



The uterine vasculature undergoes profound adaptations in response to pregnancy. Augmentation of endothelial vasodilator function and reduced smooth muscle reactivity are factors contributing to uterine artery adaptation and are critical for adequate placental perfusion. The peptide hormone relaxin has an important role in mediating the normal maternal renal vascular adaptations during pregnancy through a reduction in myogenic tone and an increase in flow-mediated vasodilation. Little is known however about the influence of endogenous relaxin on the uterine artery during pregnancy. We tested the hypothesis that relaxin deficiency increases myogenic tone and impairs endothelial vasodilator fu..

View full abstract

University of Melbourne Researchers


Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this work was supported by an Australian National Health and Medical Research Council Project Grant (LP1064845) and a University of Melbourne Early Career Researcher grant to SS. SM and MJ received Australian Postgraduate Awards.