Relaxin Deficiency Leads to Uterine Artery Dysfunction During Pregnancy in Mice
Sarah A Marshall, Sevvandi N Senadheera, Maria Jelinic, Kelly O'Sullivan, Laura J Parry, Marianne Tare
FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2018
The uterine vasculature undergoes profound adaptations in response to pregnancy. Augmentation of endothelial vasodilator function and reduced smooth muscle reactivity are factors contributing to uterine artery adaptation and are critical for adequate placental perfusion. The peptide hormone relaxin has an important role in mediating the normal maternal renal vascular adaptations during pregnancy through a reduction in myogenic tone and an increase in flow-mediated vasodilation. Little is known however about the influence of endogenous relaxin on the uterine artery during pregnancy. We tested the hypothesis that relaxin deficiency increases myogenic tone and impairs endothelial vasodilator fu..View full abstract
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Awarded by Australian National Health and Medical Research Council
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this work was supported by an Australian National Health and Medical Research Council Project Grant (LP1064845) and a University of Melbourne Early Career Researcher grant to SS. SM and MJ received Australian Postgraduate Awards.