The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function

KI Watt; CA Goodman; TA Hornberger; P Gregorevic

Journal article

The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function

KI Watt, CA Goodman, TA Hornberger, P Gregorevic

Exercise and Sport Sciences Reviews | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

DOI: 10.1249/JES.0000000000000142

Abstract

The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz) to control tissue growth in many different cell types. Previously, we demonstrated that Yap is a critical regulator of skeletal muscle mass. We hypothesize that alterations in Yap and Taz activity modulate the anabolic adaptations of skeletal muscle to resistance exercise.

University of Melbourne Researchers

Craig Goodman Author

Paul Gregorevic Author

Related Projects (1)

PRE-CLINICAL ASSESSMENT OF THE THERAPEUTIC POTENTIAL OF TARGETING THE HIPPO PATHWAY IN MUSCLE WASTING & MUSCLE-DERIVED CANCER

Recent findings have identified the Hippo signalling pathway as an important regulator of processes in muscle fibres and muscle progenitor c..

Grants

Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases

Funding Acknowledgements

The work related to this project was partially supported by a Diabetes Australia general grant awarded to K.I.W. (Y16G-WATK), a project grant (1099588) awarded to P.G. from the Australian National Health and Medical Research Council (NH&MRC), and National Institutes of Health grants AR057347 (awarded to T.A.H.) and AR063256 (awarded to C.A.G. and T.A.H.). P.G. is supported by a Senior Research Fellowship from the NH&MRC. The Baker Heart and Diabetes Institute is supported in part by the Operational Infrastructure Support Program of the Victorian Government.