Journal article
The effect of estrogenic compounds on psychosis-like behaviour in female rats
A Sbisa, M Van Den Buuse, A Gogos
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
17β-estradiol treatment has shown benefit against schizophrenia symptoms, however longterm use may be associated with negative side-effects. Selective estrogen receptor modulators, such as raloxifene and tamoxifen, have been proposed as suitable alternatives to 17β- estradiol. An isomer of 17β-estradiol, 17α-estradiol, is considered less carcinogenic, and non-feminising in males, however little is known about its potential as a treatment for schizophrenia. Moreover, the mechanism underlying the therapeutic action of estrogens remains unclear. We aimed to investigate the ability of these estrogenic compounds to attenuate psychosis-like behaviour in rats. We used two acute pharmacologically-in..
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Funding Acknowledgements
AG is supported by a Career Development Fellowship and MvdB was supported by a Senior Research Fellowship from the National Health and Medical Research Council of Australia. AG was supported by an Australian Research Council Discovery Early Career Researcher Award. The authors gratefully acknowledge the financial support of the Jared Purton Award. The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government's Operational Infrastructure Support Grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.