Journal article

Wnt Signalling in Gastrointestinal Epithelial Stem Cells

Dustin J Flanagan, Chloe R Austin, Elizabeth Vincan, Toby J Phesse

GENES | MDPI | Published : 2018

Abstract

Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is critical for embryonic development. Stem cells are defined by their ability for self-renewal and the ability to be able to give rise to differentiated progeny. Consequently, they are essential for the homeostasis of many organs including the gastrointestinal tract. This review will describe the huge advances in our understanding of how stem cell functions in the gastrointestinal tract are regulated by Wnt signalling, including how deregulated Wnt signalling can hijack these functions to transform cells and lead to cancer.

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Melbourne Health project grants


Awarded by Melbourne Health Early Career Researcher grant


Awarded by Cancer Council of Victoria (CCV)


Funding Acknowledgements

The authors wish to thank Gavan Mitchell for helping generate the figures in this manuscript. Funding is gratefully acknowledged from the following; National Health and Medical Research Council of Australia (NHMRC) project grants (566679 and APP1099302 awarded to E.V.); Melbourne Health project grants (605030 and PG-002 awarded to E.V./T.J.P.), and an Early Career Researcher grant (GIA-033) awarded to D.J.F.; Cancer Council of Victoria project grants (CCV, APP1020716) awarded to E.V. and T.J.P., CCV Fellowship awarded to D.J.F. and Cardiff University Research Fellowship awarded to T.J.P.