Journal article
Periprostatic fat tissue transcriptome reveals a signature diagnostic for high-risk prostate cancer
S Mangiola, R Stuchbery, G Macintyre, MJ Clarkson, JS Peters, AJ Costello, CM Hovens, NM Corcoran
Endocrine Related Cancer | BIOSCIENTIFICA LTD | Published : 2018
DOI: 10.1530/ERC-18-0058
Abstract
Evidence suggests that altered adipose tissue homeostasis may be an important contributor to the development and/or progression of prostate cancer. In this study, we investigated the adipose transcriptional profiles of low- and high-risk disease to determine both prognostic potential and possible biological drivers of aggressive disease. RNA was extracted from periprostatic adipose tissue from patients categorised as having prostate cancer with either a low or high risk of progression based on tumour characteristics at prostatectomy and profiled by RNA sequencing. The expression of selected genes was then quantified by qRT-PCR in a cross-validation cohort. In the first phase, a total of 677 ..
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Funding Acknowledgements
The Australian Prostate Cancer Centre Epworth is supported by the Australian Government as represented by the Department of Health and Ageing. S Mangiola is supported by the David Mayor PhD Scholarship from the Prostate Cancer Research Foundation. N M Corcoran was supported by a David Bickart Clinician Research Fellowship from the Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne, as well a Movember - Distinguished Gentleman's Ride Clinician Scientist Award through Prostate Cancer Foundation of Australia's Research Programme.