Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1
Maureen P Martin, Vivek Naranbhai, Patrick R Shea, Ying Qi, Veron Ramsuran, Nicolas Vince, Xiaojiang Gao, Rasmi Thomas, Zabrina L Brumme, Jonathan M Carlson, Steven M Wolinsky, James J Goedert, Bruce D Walker, Florencia P Segal, Steven G Deeks, David W Haas, Stephen A Migueles, Mark Connors, Nelson Michael, Jacques Fellay Show all
Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2018
Awarded by federal funds from the NCI, NIH
Awarded by NIAID under NIH
Awarded by NIH
This article is dedicated to the memory of Dr. Bonnie Mathieson, a longtime friend and colleague who dedicated her career to the advancement of HIV research. We would like to thank Victoria Walker-Sperling for her assistance with the figures. This work was supported by federal funds from the NCI, NIH, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Departments of the Army and Defense or Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. This Research was supported in part by the Intramural Research Program of the NIH, Frederick National Laboratory, Center for Cancer Research, and the National Health and Medical Research Council of Australia. Data in this manuscript were collected by the MACS and/or the Women's Interagency HIV Study (WIHS).The contents of this publication are solely the responsibility of the authors and do not represent the official views of the NIH. Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS). MACS (Principal Investigators): Johns Hopkins University Bloomberg School of Public Health (Joseph Margolick, Todd Brown), U01-AI35042; Northwestern University (Steven Wolinsky), U01-AI35039; University of California, Los Angeles (Roger Detels, Otoniel Martinez-Maza, Otto Yang), U01-AI35040; University of Pittsburgh (Charles Rinaldo, Lawrence Kingsley, Jeremy Martinson), U01-AI35041; the Center for Analysis and Management of MACS, Johns Hopkins University Bloomberg School of Public Health (Lisa Jacobson, Gypsyamber D'Souza), UM1-AI35043. The MACS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute of Mental Health (NIMH). Targeted supplemental funding for specific projects was also provided by the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute on Deafness and Communication Disorders (NIDCD). MACS data collection is also supported by UL1-TR001079 (Johns Hopkins University Institute for Clinical and Translational Research [ICTR]) from the National Center for Advancing Translational Sciences (NCATS) a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH), Johns Hopkins ICTR, or NCATS. The MACS website is located at http://aidscohortstudy.org/. The ACTG was supported by the NIAID under NIH grants AI068636, AI038858, AI068634, AI106701 and AI038855, and grants to Clinical Research Sites that participated in ACTG protocols and collected DNA under protocol A5128: AI069477, AI027675, AI073961, AI069474, AI069432, AI069513, AI069423, AI050410, AI069452, AI69450, AI054907, AI069428, AI045008, AI069495, AI069415, AI069556, AI069484, AI069424, AI069532, AI069419, AI069471, AI025859, AI069418, AI050409, AI069501, AI069502, AI069511, AI069434, AI069465, AI069494, AI069472, AI069470, AI046376, AI072626, AI027661, AI034853, AI069447, AI032782, AI027658, AI27666, AI058740, AI046370, TR000445, RR00051, RR00046, RR025747, RR025777, RR024160, RR024996, and RR024156. Abbott Laboratories, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, and GlaxoSmithKline provided study medications.DWH is also supported by NIH grants AI077505, AI110527, and TR000445. JR is supported by the National Health and Medical Research Council of Australia, the Anti-cancer Council, the Australian Research Council, and by an ARC Laureate Fellowship. ZLB is supported by a Scholar Award from the Michael Smith Foundation for Health Research. DAP is a Wellcome Trust Senior Investigator.