Journal article
Surgical practice and outcome in 711 neonates and infants undergoing hernia repair in a large multicenter RCT: Secondary results from the GAS Study
Nicola Disma, Davinia Withington, Mary Ellen McCann, Rodney Wayne Hunt, Sarah Jane Arnup, Francesca Izzo, Jurgen C de Graaff, Girolamo Mattioli, Neil Morton, Geoff Frawley, Andrew Davidson, Anne Lynn, Peter Szmuk, Joss John Thomas, Philip Ragg, Alessio Pini Prato
JOURNAL OF PEDIATRIC SURGERY | W B SAUNDERS CO-ELSEVIER INC | Published : 2018
Abstract
BACKGROUND: The GAS study is an international RCT to evaluate neurodevelopmental outcome comparing general plus regional anesthesia versus regional anesthesia alone in 722 neonates and infants who had inguinal hernia repair up to 60 weeks of postmenstrual age. This paper comprises a secondary descriptive analysis of hernias, aspects of surgery and outcomes. METHODS: The incidence of unilateral and bilateral hernias, side preponderance, predictive factors for bilateral hernias and surgical approaches were collated. Follow-up outcome data were examined at 2 years. RESULTS: Of 711 eligible patients, there were 679 with hernia data showing that 321 hernias were right-sided, 190 left and 168 bila..
View full abstractGrants
Awarded by Australian National Health & Medical Research Council
Awarded by Australian and New Zealand College of Anaesthetists
Awarded by National Institutes of Health
Awarded by Food and Drug Administration
Awarded by Italian Ministry of Heath, Ricerca Finalizzata
Awarded by Fonds Nuts Ohra grant
Awarded by Vrienden WKZ
Awarded by Canadian Institute of Health Research
Awarded by Health Technologies Assessment-National Institute for Health Research UK
Funding Acknowledgements
Australia: The Australian National Health & Medical Research Council (Project Grants #1002906 and 491226); Australian and New Zealand College of Anaesthetists (Project Grant #11/021 and 07/012); The Murdoch Childrens Research Institute. This study was supported by the Victorian Government's Operational Infrastructure Support Program.USA: National Institutes of Health (Project Grant # NIH 1-R01 HDO6 1136-01A1); Food and Drug Administration (Project Grant #FDA-SOL-08-SAFEKIDS-Clin 002-Project 2)Italy: Italian Ministry of Heath, Ricerca Finalizzata (Project Grant # RF-2011-02347532)Netherlands: Fonds Nuts Ohra grant #1305-144 and Vrienden WKZ 16.13.038Canada: Canadian Institute of Health Research (Project Grant #MCT-98031), Canadian Anesthesiologists' Society, Pfizer Canada Inc.UK: Health Technologies Assessment-National Institute for Health Research UK (Project Grant #07/01/05)