Journal article
Xerostomia, salivary characteristics and gland volumes following intensity-modulated radiotherapy for nasopharyngeal carcinoma: a two-year follow up
CPC Sim, YL Soong, EPP Pang, C Lim, GD Walker, DJ Manton, EC Reynolds, JTS Wee
Australian Dental Journal | WILEY | Published : 2018
DOI: 10.1111/adj.12608
Abstract
Background: To evaluate changes in xerostomia status, salivary characteristics and gland volumes 2 years following radiotherapy in nasopharyngeal carcinoma patients. Methods: Xerostomia scores, salivary flow rates, pH and buffering capacity were measured at pre-radiotherapy, mid-radiotherapy, 2 weeks, 3 months and 2 years post-radiotherapy. Salivary gland volumes and their correlation with radiation dose were also assessed. Results: Mean radiation dose to oral cavity, parotid and submandibular glands (SMG) was 44.5, 65.0 and 38.6 Gy respectively. Parotid and SMG volumes decreased 33% at 3 months post-radiotherapy; volumes at 2 years post-radiotherapy were 84% and 51% of pre-radiotherapy leve..
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Funding Acknowledgements
The authors would like to thank Dr Abdul Razak Ashik Hussain for contouring the respective organs at risk, and Ms Patemah Binte Salleh and Ms Loyce MH Chua for administrative support with regards to treatment planning. The contributions by Drs KW Fong, T Tan and SL Cheah from the National Cancer Centre Singapore are gratefully acknowledged. Dr Christina PC Sim is a recipient of a National Medical Research Council Research Training Fellowship. This research was supported by the National Dental Centre of Singapore Research Fund/National Medical Research Council Centre Grant. The funding body had no involvement in the study design, collection, analysis and interpretation of data, and the writing and submission of the manuscript.