Use of the waist-to-height ratio to predict cardiovascular risk in patients with diabetes: Results from the ADVANCE-ON study
Karin Radholm, John Chalmers, Toshiaki Ohkuma, Sanne Peters, Neil Poulter, Pavel Hamet, Stephen Harrap, Mark Woodward
Diabetes Obesity and Metabolism | WILEY | Published : 2018
AIMS: Patients with type 2 diabetes have a high risk of cardiovascular disease (CVD). Central obesity has been particularly associated with this risk relationship. We aimed to evaluate waist to height ratio (WHtR) as a predictor of risk in such patients. METHODS: WHtR was evaluated as a predictor of the risk of CVD and mortality amongst 11 125 participants with type 2 diabetes in the ADVANCE and ADVANCE-ON studies, and was compared with body mass index (BMI), waist circumference and waist hip ratio (WHR). Primary outcome was a composite of death from CVD, non-fatal myocardial infarction or non-fatal stroke. Secondary outcomes were myocardial infarction, stroke, cardiovascular death and death..View full abstract
Awarded by UK Medical Research Council Skills Development Fellowship
Awarded by NHMRC Fellowship
The ADVANCE trial was funded by grants from the National Health and Medical Research Council of Australia and Servier. K. R. is funded by a County Council of Ostergotland international fellowship. T. O. is supported by a JSPS Overseas Research Fellowship. J. C. received research grants from the National Health and Medical Research Council of Australia and from Servier for the ADVANCE trial and ADVANCE-ON post-trial follow-up. S. P. is supported by a UK Medical Research Council Skills Development Fellowship (MR/P014550/1). M. W. is supported by a NHMRC Fellowship (APP108026).