Journal article
The ventrolateral medulla and medullary raphe in sudden unexpected death in epilepsy
S Patodia, A Somani, M O'Hare, R Venkateswaran, J Liu, Z Michalak, M Ellis, IE Scheffer, B Diehl, SM Sisodiya, M Thom
Brain | OXFORD UNIV PRESS | Published : 2018
DOI: 10.1093/brain/awy078
Abstract
Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature death in patients with epilepsy. One hypothesis proposes that sudden death is mediated by post-ictal central respiratory depression, which could relate to underlying pathology in key respiratory nuclei and/or their neuromodulators. Our aim was to investigate neuronal populations in the ventrolateral medulla (which includes the putative human pre-Bötzinger complex) and the medullary raphe. Forty brainstems were studied comprising four groups: 14 SUDEP, six epilepsy controls, seven Dravet syndrome cases and 13 non-epilepsy controls. Serial sections through the medulla (from obex 1 to 10 mm) were stained for Nissl, soma..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study is supported by the Center for SUDEP Research (CSR) through the National Institute of Neurological Disorders And Stroke of the National Institutes of Health (Award Numbers neuropathology of SUDEP: 5U01NS090415 and SUDEP admin core grant: U01-NS090405). Z.M. was funded by the European Union's Seventh Framework Program (FP7/2007-2013) under grant agreement 602102 (EPITARGET). Epilepsy Society, through the Katy Baggott foundation supports the UCL Epilepsy Society Brain and Tissue Bank. This work was undertaken at UCLH/UCL who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme.