Negligible Impact of Mass Screening and Treatment on Mesoendemic Malaria Transmission at West Timor in Eastern Indonesia: A Cluster-Randomized Trial
Inge Sutanto, Ayleen Kosasih, Iqbal RF Elyazar, Deddy R Simanjuntak, Tri A Larasati, M Sopiyudin Dahlan, Isra Wahid, Ivo Mueller, Cristian Koepfli, Rita Kusriastuti, Asik Surya, Ferdinand J Laihad, William A Hawley, Frank H Collins, J Kevin Baird, Neil F Lobo
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2018
Background: Mass screening and treatment (MST) aims to reduce malaria risk in communities by identifying and treating infected persons without regard to illness. Methods: A cluster-randomized trial evaluated malaria incidence with and without MST. Clusters were randomized to 3, 2, or no MST interventions: MST3, 6 clusters (156 households/670 individuals); MST2, 5 clusters (89 households/423 individuals); and MST0, 5 clusters (174 households/777 individuals). All clusters completed the study with 14 residents withdrawing. In a cohort of 324 schoolchildren (MST3, n = 124; MST2, n = 57; MST0, n = 143) negative by microscopy at enrollment, we evaluated the incidence density of malaria during 3 m..View full abstract
Awarded by Bill & Melinda Gates Foundations
This project has been funded in whole or in part with funds from the Bill & Melinda Gates Foundations (grant number 45114).