Journal article
Changing vision: a review of pharmacogenetic studies for treatment response in age-related macular degeneration patients
Janan Arslan, Paul N Baird
PHARMACOGENOMICS | FUTURE MEDICINE LTD | Published : 2018
Abstract
Nonresponsiveness to age-related macular degeneration (AMD) treatments has become a growing concern in ophthalmology. Disparity among publications that have assessed pharmacogenetic (PGx) connections between AMD disease genes and treatments has delayed the implementation of PGx testing in AMD. We assessed all AMD PGx publications to identify the degree of agreement for publications within similar ethnic cohorts and worldwide, and the causes for differences in study outcomes. There are no accepted genotype-phenotype correlations, either within similar ethnic cohorts or worldwide. The diversity of measured outcomes, treatment protocols and statistical methods used may be causing this discrepan..
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Grants
Awarded by National Health and Medical Research Council of Australia (NHMRC) Senior Research Fellowship
Funding Acknowledgements
The authors acknowledge funding from the National Health and Medical Research Council of Australia (NHMRC) Senior Research Fellowship 1138585 (PN Baird). The Centre for Eye Research Australia (CERA) receives Operational Infrastructure Support from the Victorian Government. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.