Journal article
Narrow-sense heritability estimation of complex traits using identity-by-descent information
LM Evans, R Tahmasbi, M Jones, SI Vrieze, GR Abecasis, S Das, DW Bjelland, TR de Candia, J Yang, ME Goddard, PM Visscher, MC Keller
Heredity | Published : 2018
Abstract
Heritability is a fundamental parameter in genetics. Traditional estimates based on family or twin studies can be biased due to shared environmental or non-additive genetic variance. Alternatively, those based on genotyped or imputed variants typically underestimate narrow-sense heritability contributed by rare or otherwise poorly tagged causal variants. Identical-by-descent (IBD) segments of the genome share all variants between pairs of chromosomes except new mutations that have arisen since the last common ancestor. Therefore, relating phenotypic similarity to degree of IBD sharing among classically unrelated individuals is an appealing approach to estimating the near full additive geneti..
View full abstractGrants
Awarded by Sylvia and Charles Viertel Charitable Foundation
Funding Acknowledgements
This work utilized the Janus supercomputer, which is supported by the National Science Foundation (award number CNS-0821794), the University of Colorado Boulder, the University of Colorado Denver, and the National Center for Atmospheric Research, and is operated by the University of Colorado Boulder. This research has been conducted using the UK Biobank Resource. We thank the participants of the individual HRC cohorts and the UK Biobank. We thank the Keller and Vrieze lab groups, the Institute for Behavioral Genetics, and Sean Caron. This study was funded by NIH R01MH100141 (MCK), NIH R01DA037904 and R01HG008983 (SV), NHMRC grants 1078037 (PMV) and 1113400 (PMV and JY), and Sylvia & Charles Viertel Charitable Foundation Senior Medical Research Fellowship (JY).