A comparative study of the effect of submicron porous and smooth ultrafine-grained Ti-20Mo surfaces on osteoblast responses

N Gui; W Xu; AN Abraham; DE Myers; ELH Mayes; K Xia; R Shukla; M Qian

Journal article

A comparative study of the effect of submicron porous and smooth ultrafine-grained Ti-20Mo surfaces on osteoblast responses

N Gui, W Xu, AN Abraham, DE Myers, ELH Mayes, K Xia, R Shukla, M Qian

Journal of Biomedical Materials Research Part A | WILEY | Published : 2018

DOI: 10.1002/jbm.a.36402

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Abstract

The surface of an orthopaedic implant plays a crucial role in determining the adsorption of proteins and cell functions. A detailed comparative study has been made of the in vitro osteoblast responses to coarse-grained (grain size: 500 μm), ultrafine-grained (grain size: 100 nm), coarse-porous (pore size: 350 nm), and fine-porous (pore size: 155 nm) surfaces of Ti-20Mo alloy. The purpose was to provide essential experimental data for future design of orthopaedic titanium implants for rapid osseointegration. Systematic original experimental data was produced for each type of surfaces in terms of surface wettability, cell morphology, adhesion, growth, and differentiation. Microscopic evidence ..

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University of Melbourne Researchers

Damian Myers Author

Kenong Xia Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

Contract grant sponsor: China Scholarship Council (CSC) (to N.G.)Contract grant sponsor: Ian Potter Foundation (to R.S.)Contract grant sponsor: Maxwell Eagle Endowment from RMIT University (to R.S.)Contract grant sponsor: Australian Research Council (ARC); contract grant number: ARC LP140100607