Itraconazole Dosing and Drug Monitoring at a Tertiary Children’s Hospital

Abstract

Background: Itraconazole is a broad-spectrum antifungal agent used for prophylaxis and treatment of fungal infections in immunocompromised children. Achieving the recommended target serum itraconazole trough concentration of ≥0.5 mg/L is challenging in children because of variation in itraconazole pharmacokinetics with age. We studied itraconazole use and treatment outcomes in a tertiary children’s hospital. Methods: We did a 10-year retrospective review of medical records of children at the Royal Children’s Hospital Melbourne who received oral itraconazole and had therapeutic drug monitoring (TDM). Results: Overall, 81 children received 92 courses of oral itraconazole and had TDM. Of 222 TD..