Journal article

Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae

Sundeep Chaitanya Vedithi, Sony Malhotra, Madhusmita Das, Sheela Daniel, Nanda Kishore, Anuja George, Shantha Arumugam, Lakshmi Rajan, Mannam Ebenezer, David B Ascher, Eddy Arnold, Tom L Blundell



Awarded by American leprosy Missions Grant

Awarded by Wellcome Trust

Awarded by MRC Newton Award

Awarded by Fundacao de Amparo a Pesquisa do Estado de Minas Gerais

Funding Acknowledgements

We thank Dr. Bernardo Ochoa for his suggestions and discussions on mapping interatomic interactions. We thank the director, administrative and research staff of SIH-R&LC Karigiri for the infrastructural and financial support to conduct experiments. We acknowledge the contributions of clinical and support staff at the Father Muller Foundation, Mangalore and Government Medical College, Trivandrum for clinical assessment of relapse and MDT-non-respondent leprosy cases and shipment of samples. SCV was supported by American leprosy Missions Grant (G88726); TLB was supported by the Wellcome Trust Programme Grant (200814/Z/16/Z); SM was supported by the MRC Newton Award (RG78439). DBA was funded by a Newton Fund RCUK-CONFAP Grant awarded by The Medical Research Council and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (MR/M026302/1).