Journal article
Perioperative events influence cancer recurrence risk after surgery
JG Hiller, NJ Perry, G Poulogiannis, B Riedel, EK Sloan
Nature Reviews Clinical Oncology | Published : 2018
Abstract
Surgery is a mainstay treatment for patients with solid tumours. However, despite surgical resection with a curative intent and numerous advances in the effectiveness of (neo)adjuvant therapies, metastatic disease remains common and carries a high risk of mortality. The biological perturbations that accompany the surgical stress response and the pharmacological effects of anaesthetic drugs, paradoxically, might also promote disease recurrence or the progression of metastatic disease. When cancer cells persist after surgery, either locally or at undiagnosed distant sites, neuroendocrine, immune, and metabolic pathways activated in response to surgery and/or anaesthesia might promote their sur..
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Awarded by National Cancer Institute
Awarded by Cancer Research UK Grand Challenge award
Funding Acknowledgements
The work of the authors is supported by the Australian and New Zealand College of Anaesthetists, The David and Lorelle Skewes Foundation, the Peter Mac Foundation, and the National Cancer Institute (CA160890). N.J.P is the recipient of a Cancer Research UK Clinical Research Fellowship. Work in the G.P lab is supported by the British Journal of Anaesthesia/Royal College of Anaesthetists via the National Institute of Academic Anaesthesia, Cancer Research UK Grand Challenge award (C59824/A25044), and the Institute of Cancer Research. Author contributions J.G.H, N.J.P, B.R, and E.K.S researched data for the article. All authors wrote, reviewed, and edited the manuscript before submission. J.G.H and N.J.P contributed equally.