IL-11 is a crucial determinant of cardiovascular fibrosis

Sebastian Schafer; Sivakumar Viswanathan; Anissa A Widjaja; Wei-Wen Lim; Aida Moreno-Moral; Daniel M DeLaughter; Benjamin Ng; Giannino Patone; Kingsley Chow; Ester Khin; Jessie Tan; Sonia P Chothani; Lei Ye; Owen JL Rackham; Nicole SJ Ko; Norliza E Sahib; Chee Jian Pua; Nicole TG Zhen; Chen Xie; Mao Wang; Henrike Maatz; Shiqi Lim; Kathrin Saar; Susanne Blachut; Enrico Petretto; Sabine Schmidt; Tracy Putoczki; Nuno Guimaraes-Camboa; Hiroko Wakimoto; Sebastiaan van Heesch; Kristmundur Sigmundsson; See L Lim; Jia L Soon; Victor TT Chao; Yeow L Chua; Teing E Tan; Sylvia M Evans; Yee J Loh; Muhammad H Jamal; Kim K Ong; Kim C Chua; Boon-Hean Ong; Mathew J Chakaramakkil; Jonathan G Seidman; Christine E Seidman; Norbert Hubner; Kenny YK Sin; Stuart A Cook

Journal article

IL-11 is a crucial determinant of cardiovascular fibrosis

Sebastian Schafer, Sivakumar Viswanathan, Anissa A Widjaja, Wei-Wen Lim, Aida Moreno-Moral, Daniel M DeLaughter, Benjamin Ng, Giannino Patone, Kingsley Chow, Ester Khin, Jessie Tan, Sonia P Chothani, Lei Ye, Owen JL Rackham, Nicole SJ Ko, Norliza E Sahib, Chee Jian Pua, Nicole TG Zhen, Chen Xie, Mao Wang Show all

Nature | NATURE PUBLISHING GROUP | Published : 2017

DOI: 10.1038/nature24676

University of Melbourne Researchers

Tracy Putoczki Author Surgery - Royal Melbourne Hospital

Grants

Awarded by National Medical Research Council (NMRC) Singapore STaR award

Awarded by NHLBI

Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

Awarded by OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

Awarded by Medical Research Council

Funding Acknowledgements

We thank all patients for taking part in this research, which was performed with approval from the SingHealth Centralised IRB Review Board (CIRB; 2013/103/C). The research was supported by the National Medical Research Council (NMRC) Singapore STaR award (S.A.C.) (NMRC/STaR/0011/2012), the NMRC Centre Grant to the National Heart Centre Singapore (NHCS), Goh Foundation, Tanoto Foundation, NHLBI 5R01HL080494 (J.G.S., C.E.S.), HHMI (C.E.S.) and a grant from the Fondation Leducq (N.H., J.G.S., C.E.S., S.C.). We thank I. Kamer and R. Plehm, Max-Delbruck-Center for Molecular Medicine (MDC), for expert technical help with telemetry blood pressure measurements.