Idiopathic infertility in women is associated with distinct changes in proliferative phase uterine fluid proteins
Harriet C Fitzgerald, Jemma Evans, Nicholas Johnson, Giuseppe Infusini, Andrew Webb, Luk JR Rombauts, Beverley J Vollenhoven, Lois A Salamonsen, Tracey A Edgell
Biology of Reproduction | OXFORD UNIV PRESS INC | Published : 2018
The regenerative, proliferative phase of a woman's menstrual cycle is a critical period which lays the foundation for the subsequent, receptive secretory phase. Although endometrial glands and their secretions are essential for embryo implantation and survival, the proliferative phase, when these glands form, has been rarely examined. We hypothesized that alterations in the secreted proteome of the endometrium of idiopathic infertile women would reflect a disturbance in proliferative phase endometrial regeneration. Our aim was to compare the proteomic profile of proliferative phase uterine fluid from fertile (n = 9) and idiopathic infertile (n = 10) women. Proteins with ≥2-fold change (P < 0..View full abstract
Awarded by NHMRC Fellowship
This work was supported by NHMRC Fellowship to LAS (#1002028), the Victorian Government's Operational Infrastructure Support Program, and the L.E.W. Carty Charitable Fund. HCF was supported by Monash University Medicine, Nursing and Health Sciences Faculty Postgraduate Research Scholarship.