Long-term maintenance of virus-specific effector memory CD8 T cells in the lung airways depends on proliferation.
Robert J Hogan, Linda S Cauley, Kenneth H Ely, Tres Cookenham, Alan D Roberts, Jean W Brennan, Simon Monard, David L Woodland
The Journal of Immunology | Published : 2002
Recent studies have shown that virus-specific effector memory T cells can be recovered from the lung airways long after clearance of a respiratory virus infection. These cells are thought to play an important role in the recall response to secondary viral infection. It is currently unclear whether these cells actually persist at this site or are maintained by continual proliferation and recruitment. In this study, we have analyzed the mechanisms underlying the persistence of memory CD8(+) T cells in the lung airway lumina following recovery from a respiratory virus infection. The data identify two distinct populations of memory cells. First, a large population Ag-specific CD8(+) T cells is d..View full abstract
Awarded by NIAID NIH HHS
Awarded by NHLBI NIH HHS