Journal article

Expression patterns of the HIV type 1 coreceptors CCR5 and CXCR4 on CD4 T cells and monocytes from cord and adult blood.

H Mo, S Monard, H Pollack, J Ip, G Rochford, L Wu, J Hoxie, W Borkowsky, DD Ho, JP Moore

AIDS Research and Human Retroviruses | Published : 1998

Abstract

We have measured the surface expression of the HIV-1 coreceptors CCR5 and CXCR4 on CD4+ T cells and monocytes from cord and adult blood. The expression of CCR5 was largely restricted to the memory (CD45RAlow) subset, whereas CXCR4 was expressed on both memory and naive (CD45RAhigh) T cells. The paucity of memory CD4+ T cells in cord blood means that CCR5-positive cells are relatively uncommon, so the overall extent of CCR5 expression was reduced in cord blood, compared with adult blood. IL-2 activation of CD4+ T cells from both cord and adult bloods caused a substantial increase in CCR5 expression, but moderately decreased CXCR4 expression. PHA stimulation increased CCR5 expression slightly,..

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University of Melbourne Researchers