Journal article
Exploring and exploiting the connection between mitochondria and the virulence of human pathogenic fungi
Surbhi Verma, Viplendra PS Shakya, Alexander Idnurm
VIRULENCE | TAYLOR & FRANCIS INC | Published : 2018
Abstract
Mitochondria are best known for their role in the production of ATP; however, recent research implicates other mitochondrial functions in the virulence of human pathogenic fungi. Inhibitors of mitochondrial succinate dehydrogenase or the electron transport chain are successfully used to combat plant pathogenic fungi, but similar inhibition of mitochondrial functions has not been pursued for applications in medical mycology. Advances in understanding mitochondrial function relevant to human pathogenic fungi are in four major directions: 1) the role of mitochondrial morphology in virulence, 2) mitochondrial genetics, with a focus on mitochondrial DNA recombination and mitochondrial inheritance..
View full abstractGrants
Awarded by National Institutes of Health
Awarded by Australian Research Council
Funding Acknowledgements
Our work on mitochondrial functions in pathogenic fungi was supported by the National Institutes of Health grant R21 AI094364 and the Australian Research Council grant FT130100146.