Journal article

2-Nitrobenzohydrazide as a Potent Urease Inhibitor: Synthesis, Characterization and Single Crystal X-ray Diffraction Analysis

Naeem Abbas, Imtiaz Khan, Sadaf Batool, Majid Ali, Umar Farooq, Ajmal Khan, Shahid Hameed, Jonathan M White, Aliya Ibrar

Journal of the Chemical Society of Pakistan | CHEM SOC PAKISTAN | Published : 2018

Abstract

2-Nitrobenzohydrazide was efficiently synthesized in two steps by the esterification of 2-nitrobenzoic acid followed by the treatment with hydrazine hydrate in methanol. The structure of 2-nitrobenzohydrazide was established by modern spectro-analytical techniques including FTIR,1H and13C-NMR spectroscopy and unequivocally confirmed by single crystal X-ray diffraction data. 2-Nitrobenzohydrazide crystallized in orthorhombic space group P 21 21 21 with unit cell dimensions a = 4.9764(4) Å, b = 12.5280 (3) Å, c = 12.8512(1) Å, α = β = γ = 90°. A combination of N‒H…N and N‒H…O hydrogen bonds stabilized the crystal packing of 3. The synthesized compound 3 was assessed as urease inhibitor against..

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University of Melbourne Researchers

Grants

Awarded by Higher Education Commission of Pakistan


Funding Acknowledgements

Generous support from Higher Education Commission of Pakistan (project No. 21978/SRGP/R&D/HEC/2016) is gratefully acknowledged.