Journal article

2-Nitrobenzohydrazide as a Potent Urease Inhibitor: Synthesis, Characterization and Single Crystal X-ray Diffraction Analysis

Naeem Abbas, Imtiaz Khan, Sadaf Batool, Majid Ali, Umar Farooq, Ajmal Khan, Shahid Hameed, Jonathan M White, Aliya Ibrar

Journal of the Chemical Society of Pakistan | CHEM SOC PAKISTAN | Published : 2018


2-Nitrobenzohydrazide was efficiently synthesized in two steps by the esterification of 2-nitrobenzoic acid followed by the treatment with hydrazine hydrate in methanol. The structure of 2-nitrobenzohydrazide was established by modern spectro-analytical techniques including FTIR,1H and13C-NMR spectroscopy and unequivocally confirmed by single crystal X-ray diffraction data. 2-Nitrobenzohydrazide crystallized in orthorhombic space group P 21 21 21 with unit cell dimensions a = 4.9764(4) Å, b = 12.5280 (3) Å, c = 12.8512(1) Å, α = β = γ = 90°. A combination of N‒H…N and N‒H…O hydrogen bonds stabilized the crystal packing of 3. The synthesized compound 3 was assessed as urease inhibitor against..

View full abstract

University of Melbourne Researchers


Awarded by Higher Education Commission of Pakistan

Funding Acknowledgements

Generous support from Higher Education Commission of Pakistan (project No. 21978/SRGP/R&D/HEC/2016) is gratefully acknowledged.