Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs
Phillip L van der Peet, Christian Gunawan, Alaa Abdul-Ridha, Sherie Ma, Daniel J Scott, Andrew L Gundlach, Ross AD Bathgate, Jonathan M White, Spencer J Williams
METHODSX | ELSEVIER SCIENCE BV | Published : 2018
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We thank the Australian Research Council and the National Health and Medical Research Council (NHMRC) Australia for grant support. We thank Dr. Sebastian Marcuccio (Advanced Molecular Technologies) for helpful discussions, and Prof. Arthur Christopoulos (Monash Institute for Pharmaceutical Sciences) for providing the FlpIn CHO M<INF>1</INF> DREADD cell line. A.A. is an NHMRC-ARC Dementia Research Development Fellow and R.A.D.B. is an NHMRC Senior Research Fellow. Studies at The Florey were supported by the Victorian Government Operational Infrastructure Support Program.