Journal article

An objective in vivo diagnostic method for inflammatory bowel disease

Sophie C Payne, Robert K Shepherd, Alicia Sedo, James B Fallon, John B Furness

ROYAL SOCIETY OPEN SCIENCE | ROYAL SOC | Published : 2018

Abstract

Inflammatory damage to the bowel, as occurs in inflammatory bowel disease (IBD), is debilitating to patients. In both patients and animal experimental models, histological analyses of biopsies and endoscopic examinations are used to evaluate the disease state. However, such measurements often have delays and are invasive, while endoscopy is not quantitatively objective. Therefore, a real-time quantitative method to assess compromised mucosal barrier function is advantageous. We investigated the correlation of in vivo changes in electrical transmural impedance with histological measures of inflammation. Four platinum (Pt) ball electrodes were placed in the lumen of the rat small intestine, wi..

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Grants

Awarded by Defense Advanced Research Projects Agency (DARPA) BTO under the auspices of Dr Doug Weber through the Space and Naval Warfare Systems Center


Funding Acknowledgements

This work was sponsored by the Defense Advanced Research Projects Agency (DARPA) BTO under the auspices of Dr Doug Weber through the Space and Naval Warfare Systems Center (Contract no. N66001-15-2-4060). The Bionics Institute and the Florey Institute of Neuroscience and Mental Health acknowledge the support they receive from the Victorian Government through its Operational Infrastructural Support Program.