Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

Li Ding; Matthew H Bailey; Eduard Porta-Pardo; Vesteinn Thorsson; Antonio Colaprico; Denis Bertrand; David L Gibbs; Amila Weerasinghe; Kuan-lin Huang; Collin Tokheim; Isidro Cortes-Ciriano; Reyka Jayasinghe; Feng Chen; Lihua Yu; Sam Sun; Catharina Olsen; Jaegil Kim; Alison M Taylor; Andrew D Cherniack; Rehan Akbani; Chayaporn Suphavilai; Niranjan Nagarajan; Joshua M Stuart; Gordon B Mills; Matthew A Wyczalkowski; Benjamin G Vincent; Carolyn M Hutter; Jean Claude Zenklusen; Katherine A Hoadley; Michael C Wendl; Llya Shmulevich; Alexander J Lazar; David A Wheeler; Gad Getz

Journal article

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

Li Ding, Matthew H Bailey, Eduard Porta-Pardo, Vesteinn Thorsson, Antonio Colaprico, Denis Bertrand, David L Gibbs, Amila Weerasinghe, Kuan-lin Huang, Collin Tokheim, Isidro Cortes-Ciriano, Reyka Jayasinghe, Feng Chen, Lihua Yu, Sam Sun, Catharina Olsen, Jaegil Kim, Alison M Taylor, Andrew D Cherniack, Rehan Akbani Show all

CELL | CELL PRESS | Published : 2018

DOI: 10.1016/j.cell.2018.03.033

Abstract

The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor an..

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University of Melbourne Researchers

Christopher Hovens Author

Michael Lawrence Author

Alex Boussioutas Author

Niall Corcoran Author

Grants

Awarded by NIH

Awarded by NATIONAL CANCER INSTITUTE

Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE

Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

Awarded by NATIONAL INSTITUTE ON DRUG ABUSE

Funding Acknowledgements

We thank patients who contributed to this study and the NCI Office of Cancer Genomics and acknowledge NIH grants U54 HG003273, U54 HG003067, U54 HG003079, U24 CA143799, U24 CA143835, U24 CA143840, U24 CA143843, U24 CA143845, U24 CA143848, U24 CA143858, U24 CA143866, U24 CA143867, U24 CA143882, U24 CA143883, U24 CA144025, U24 CA211006, and P30 CA016672.