Journal article

Isoflurane post-conditioning influences myocardial infarct healing in rats.

I Agnic, N Filipovic, K Vukojevic, M Saraga-Babic, I Grkovic

Biotech Histochem | Published : 2018


Isoflurane post-conditioning causes an early increase in cardiac progenitor cells; however, during the chronic phase of infarct healing, the number was smaller compared to control, which suggests a positive effect on infarct scar maturity. Myofibroblasts participate in early phase infarct contraction, but their number is small in a mature scar. We investigated whether isoflurane post-conditioning stimulates differentiation of progenitor cells to myofibroblasts and to verify our hypothesis that isoflurane post-conditioning improves maturation of a myocardial scar. Ischemia was induced for 30 min in female rats. From the last 5 min of ischemia until 10 min into reperfusion, the isoflurane grou..

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University of Melbourne Researchers