Journal article
Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections
Andrew E Armitage, Andrea R Stacey, Eleni Giannoulatou, Elizabeth Marshall, Pamela Sturges, Kamaljit Chatha, Nicola MG Smith, XiaoJie Huang, XiaoNing Xu, Sant-Rayn Pasricha, Ning Li, Hao Wu, Craig Webster, Andrew M Prentice, Pierre Pellegrino, Ian Williams, Phillip J Norris, Hal Drakesmith, Persephone Borrow
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2014
Abstract
During HIV type-1 (HIV-1), hepatitis C virus (HCV), and hepatitis B virus (HBV) infections, altered iron balance correlates with morbidity. The liver-produced hormone hepcidin dictates systemic iron homeostasis. We measured hepcidin, iron parameters, cytokines, and inflammatory markers in three cohorts: plasma donors who developed acute HIV-1, HBV, or HCV viremia during the course of donations; HIV-1-positive individuals progressing from early to chronic infection; and chronically HIV-1-infected individuals (receiving antiretroviral therapy or untreated). Hepcidin increased and plasma iron decreased during acute HIV-1 infection, as viremia was initially detected. In patients transitioning fr..
View full abstractGrants
Awarded by Medical Research Council UK Grant MRC
Awarded by UK Department for International Development (DFID), under MRC/DFID Concordat Agreement
Awarded by Division of AIDS Center for HIV/AIDS Vaccine Immunology
Awarded by Major Project of Beijing Municipal Science and Technology Committee
Awarded by Chinese Government 12th Five-Year Plan
Awarded by Beijing Key Laboratory
Awarded by Medical Research Council
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Funding Acknowledgements
We thank the study participants and volunteers and Selvaraj Nambiar, Reza Morovat, and Tim James for CRP analysis. This study was supported by Medical Research Council UK Grant MRC G0700844 (to H. D.) and the UK Department for International Development (DFID), under the MRC/DFID Concordat Agreement, Grant MC-A760-5QX00 (to the International Nutrition Group); the National Institutes of Health; National Institute of Allergy and Infectious Diseases; Division of AIDS Center for HIV/AIDS Vaccine Immunology (U19AI067854); the National Institute for Health Research Oxford Biomedical Research Centre; and the Major Project of Beijing Municipal Science and Technology Committee (D141100000314005 and D141100000314002), the Chinese Government 12th Five-Year Plan (2012ZX10001-003, 2012ZX10001-006, and 2012ZX10004904-002-002), and Beijing Key Laboratory (BZ0089, 2014AZYJ01). P.B. is a Jenner Institute investigator.