Journal article
Urolithiasis is prevalent and associated with reduced bone mineral density in β-thalassaemia major
P Wong, F Milat, PJ Fuller, PG Kerr, JCG Doery, DH Oh, D Jackson, MT Gillespie, DK Bowden, SR Pasricha, KK Lau
Internal Medicine Journal | WILEY | Published : 2017
DOI: 10.1111/imj.13533
Abstract
Asymptomatic urolithiasis is common and of mixed composition in patients with β-thalassaemia major. Twenty-seven subjects were imaged using dual-energy computer tomography to determine the presence and composition of urolithiasis. The prevalence of urolithiasis was 59% and affected patients generally had multiple stones, often with more than one component: struvite (33%), calcium oxalate (31%) and cystine (22%). Hypercalciuria was present in 78% of subjects and calcium-containing urolithiasis was associated with reduced femoral neck Z scores.
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
P. Wong was supported by an Australian Postgraduate Scholarship and Royal Australasian College of Physicians and Osteoporosis Australia Scholarship. S.-R. Pasricha was supported by a National Health and Medical Research Council (Australia) CJ Martin Early Career Fellowship and a New Investigator Grant from the Haematology Society of Australia and New Zealand. P. J. Fuller is supported by a National Health and Medical Research Council (Australia) Senior Principal Research Fellowship (grant number 1002559). Hudson Institute of Medical Research is supported by the Victorian Government's Operational Infrastructure Support program.