Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia
Andrew E Armitage, Pei Jin Lim, Joe N Frost, Sant-Rayn Pasricha, Elizabeth J Soilleux, Emma Evans, Alireza Morovat, Ana Santos, Rebeca Diaz, Daniel Biggs, Benjamin Davies, Uzi Gileadi, Peter A Robbins, Samira Lakhal-Littleton, Hal Drakesmith
Journal of Innate Immunity | KARGER | Published : 2016
Awarded by Wellcome Trust
Awarded by British Heart Foundation
Awarded by Medical Research Council
The authors thank Terry Rabbitts and Osama Al-Assar (WIMM, Oxford, UK) for providing Rosa-CreER<SUP>T2</SUP> mice; Craig Webster (Birmingham Heartlands Hospital, UK) for facilitating the acquisition of serum iron and Tsat data; the staff of the University of Oxford Department of Biomedical Services for animal husbandry; the staff of the Oxford Centre for Histopathology Research (OCHRe) for preparation of histology slides, and Vincenzo Cerundolo, Osama Al-Assar and Philip Hublitz (WIMM, Oxford, UK) for helpful advice and discussions. This work was supported by the Medical Research Council UK (MRC Centenary Award to A.E.A. and M.R.C. Human Immunology Unit core funding to H.D.), a Goodger and Schorstein Scholarship to A.E.A., the British Heart Foundation (Intermediate Science Research Fellowship to S.L.-L.) and by funding from Vifor Pharma to B.D., P.A.R. and S.L.-L. B.D., R.D., D.B. and A.S. were supported by Wellcome Trust Core Award Grant Number 090532/Z/09/Z.