Journal article
Toward worldwide hepcidin assay harmonization: Identification of a commutable secondary reference material
LN Van Der Vorm, JCM Hendriks, CM Laarakkers, S Klaver, AE Armitage, A Bamberg, AJ Geurts-Moespot, D Girelli, M Herkert, O Itkonen, RJ Konrad, N Tomosugi, M Westerman, SS Bansal, N Campostrini, H Drakesmith, M Fillet, G Olbina, SR Pasricha, KR Pitts Show all
Clinical Chemistry | AMER ASSOC CLINICAL CHEMISTRY | Published : 2016
Abstract
BACKGROUND: Absolute plasma hepcidin concentrations measured by various procedures differ substantially, complicating interpretation of results and rendering reference intervals method dependent. We investigated the degree of equivalence achievable by harmonization and the identification of a commutable secondary reference material to accomplish this goal. METHODS: We applied technical procedures to achieve harmonization developed by the Consortium for Harmonization of Clinical Laboratory Results. Eleven plasma hepcidin measurement procedures (5 mass spectrometry based and 6 immunochemical based) quantified native individual plasma samples (n<32) and native plasma pools (n<8) to assess analy..
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Awarded by Medical Research Council