Cytological changes in the conjunctiva in the megaloblastic anemias

Abstract

An attempt has been made to demonstrate increased nuclear size of the conjunctival cells in the megaloblastic anemias. Conjunctival scrapings were taken, wet fixation employed, and nuclear diameters measured under the microscope. The resulting data was subjected to statistical analysis. Two approximate tests of the null hypothesis that the affected group has the same nuclear size as the control group have been performed. Both tests reject this hypothesis at the 5 to 10% level.