Journal article

Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses

Jodie N Painter, Tracy A O'Mara, Andrew P Morris, Timothy HT Cheng, Maggie Gorman, Lynn Martin, Shirley Hodson, Angela Jones, Nicholas G Martin, Scott Gordon, Anjali K Henders, John Attia, Mark McEvoy, Elizabeth G Holliday, Rodney J Scott, Penelope M Webb, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Alexander Hein Show all

Cancer Medicine | WILEY | Published : 2018

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Wellcome Trust


Awarded by NHMRC


Awarded by Cancer Council Queensland


Awarded by Cancer Council Tasmania


Awarded by Cancer Research UK


Awarded by UK Medical Research Council


Awarded by Wellcome Trust Centre for Human Genetics Core Grant


Awarded by European Community's Seventh Framework Programme


Awarded by US National Institutes of Health


Awarded by US Department of Defense


Awarded by National Cancer Institute of the US Public Health Service


Awarded by Stockholm County Council


Awarded by Karolinska Institutet


Awarded by Swedish Labor Market Insurance


Awarded by Swedish Cancer Society


Awarded by Ovarian Cancer Research Fund


Awarded by National Cancer Institute (USA)


Awarded by U.S. Army Medical Research and Materiel Command


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Funding Acknowledgements

We acknowledge with appreciation all women who participated in the QIMR Berghofer Medical Research Institute and OXGENE endometriosis studies and the ANECS-SEARCH, NSECG, and iCOGS endometrial cancer studies. For the endometriosis study, we thank Endometriosis Associations for supporting study recruitment, and the many hospital directors and staff, gynecologists, general practitioners, and pathology services in Australia and the UK who provided assistance with blood collection and confirming diagnoses. We are grateful to the many research assistants and interviewers for assistance with the studies contributing to the QIMR and OXGENE collections. The QIMR Study was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (241944, 339462, 389927,389875, 389891, 389892, 389938, 443036, 442915, 442981, 496610, 496739, 552485, and 552498), the Cooperative Research Centre for Discovery of Genes for Common Human Diseases (CRC), Cerylid Biosciences (Melbourne), and donations from Neville and Shirley Hawkins. Genotyping of the OXGENE and QIMR cases was supported by a grant from the Wellcome Trust (WT084766/Z/08/Z) and makes use of WTCCC2 control data generated by the Wellcome Trust Case Control Consortium (full list of investigators at ). Funding for the WTCCC project was provided by the Wellcome Trust under award 076113 and 085475. For the endometrial cancer studies, ANECS recruitment was supported by project grants from the NHMRC (339435), Cancer Council Queensland (4196615), and Cancer Council Tasmania (403031 and 457636). The University of Newcastle, the Gladys M. Brawn Senior Research Fellowship scheme, the Vincent Fairfax Family Foundation, the Hunter Medical Research Institute, and the Hunter Area Pathology Service all contributed toward the costs of establishing the control dataset (HCS). SEARCH recruitment was funded by a program grant from Cancer Research UK (C490/A10124). Stage 1 and stage 2 case genotyping was supported by the NHMRC (552402 and 1031333). Control data were generated by the WTCCC, and we acknowledge use of DNA from the British 1958 Birth Cohort collection, funded by UK Medical Research Council grant G0000934 and Wellcome Trust grant 068545/Z/02; funding for this project was provided by the Wellcome Trust under award 085475. NSECG case recruitment was supported by the European Union's Framework Programme 7 CHIBCHA grant and Wellcome Trust Centre for Human Genetics Core Grant 090532/Z/09Z, and control (CORGI) recruitment by Cancer Research UK. The iCOGS endometrial cancer analysis was supported by an NHMRC project grant (1031333). Funding for iCOGS infrastructure came from the European Community's Seventh Framework Programme under grant agreement 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, and C8197/A16565), the US National Institutes of Health (R01 CA128978, U19 CA148537, U19 CA148065, and U19 CA148112), the US Department of Defense (W81XWH-10-1-0341), and the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, the Susan G. Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The Bavarian Endometrial Cancer Study (BECS) was partly funded by the ELAN fund of the University of Erlangen. The Hannover-Jena Endometrial Cancer Study was partly supported by the Rudolf Bartling Foundation.The Leuven Endometrium Study (LES) was supported by the Verelst Foundation for Endometrial Cancer. The Mayo Endometrial Cancer Study (MECS) and Mayo controls (MAY) were supported by grants from the National Cancer Institute of the US Public Health Service (R01 CA122443, P30 CA15083, and P50 CA136393), the Fred C. and Katherine B. Andersen Foundation, the Mayo Foundation, and the Ovarian Cancer Research Fund with support of the Smith family, in memory of Kathryn Sladek Smith. MoMaTEC received financial support from a Helse Vest Grant, the University of Bergen, the Melzer Foundation, the Norwegian Cancer Society (Harald Andersens legat), the Research Council of Norway, and Haukeland University Hospital. The Newcastle Endometrial Cancer Study (NECS) acknowledges contributions from the University of Newcastle, the NBN Children's Cancer Research Group, and Jennie Thomas and the Hunter Medical Research Institute. RENDOCAS was supported through the regional agreement on medical training and clinical research (ALF) between the Stockholm County Council and Karolinska Institutet (20110222, 20110483, 20110141, and DF 07015), Swedish Labor Market Insurance (100069), and the Swedish Cancer Society (11 0439). The Cancer Hormone Replacement Epidemiology in Sweden study (CAHRES; formerly called the Singapore and Swedish Breast/Endometrial Cancer study, SASBAC) was supported by funding from the Agency for Science, Technology and Research of Singapore (A*STAR), the US National Institutes of Health, and the Susan G. Komen Breast Cancer Foundation. For the iCOG controls, BCAC is funded by Cancer Research UK (C1287/A10118 and C1287/A12014). OCAC is supported by a grant from the Ovarian Cancer Research Fund thanks to donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07) and the UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge. The Australian Breast Cancer Family Study (ABCFS) was supported by grant UM1 CA164920 from the National Cancer Institute (USA). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the USA Government or the BCFR. The ABCFS was also supported by the National Health and Medical Research Council of Australia, the New South Wales Cancer Council, the Victorian Health Promotion Foundation (Australia) and the Victorian Breast Cancer Research Consortium. The AOCS gratefully acknowledge the cooperation of the participating institutions in Australia and also acknowledge the contribution of the study nurses, research assistants, and all clinical and scientific collaborators. A complete list of the AOCS Study Group can be found at www.aocstudy.org. AOCS was supported by the U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729, The Cancer Council Victoria, Queensland Cancer Fund, The Cancer Council New South Wales, The Cancer Council South Australia, The Cancer Foundation of Western Australia, The Cancer Council Tasmania, and the National Health and Medical Research Council of Australia (NHMRC; ID400413, ID400281). The AOCS gratefully acknowledges additional support from Ovarian Cancer Australia and the Peter MacCallum Foundation. ABS and JLH are supported by NHMRC Senior Research Fellowships. TOM is supported by an NHMRC Early Career Fellowship. GWM is supported by an NHMRC Principal Research Fellowship.APM is supported by a Wellcome Senior Fellowship in Basic Biomedical Science. SM is supported by an Australian Research Council Fellowship. The Cox research group is supported by the Sheffield Experimental Cancer Medicine Centre and Breast Cancer Now.