Journal article
Bioinformatic approaches for predicting substrates of proteases
J Song, H Tan, SE Boyd, H Shen, K Mahmood, GI Webb, T Akutsu, JC Whisstock, RN Pike
Journal of Bioinformatics and Computational Biology | WORLD SCIENTIFIC PUBL CO PTE LTD | Published : 2011
Abstract
Proteases have central roles in "life and death" processes due to their important ability to catalytically hydrolyze protein substrates, usually altering the function and/or activity of the target in the process. Knowledge of the substrate specificity of a protease should, in theory, dramatically improve the ability to predict target protein substrates. However, experimental identification and characterization of protease substrates is often difficult and time-consuming. Thus solving the "substrate identification" problem is fundamental to both understanding protease biology and the development of therapeutics that target specific protease-regulated pathways. In this context, bioinformatic p..
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Awarded by Australian Research Council
Funding Acknowledgements
JS would like to thank the National Health and Medical Research Council of Australia (NHMRC) and the Japan Society for the Promotion of Science (JSPS) for financially supporting this research via the NHMRC Peter Doherty and JSPS Post-doctoral Fellowships. JS was also supported by the Hundreds of Talents Fellowship Program of the Chinese Academy of Sciences (CAS). HS was supported by the National Natural Science Foundation of China (60704047), Science and Technology Commission of Shanghai Municipality (08ZR1410600, 08JC1410600), and sponsored by Shanghai Pujiang Program and Innovation Program of Shanghai Municipal Education Commission (10ZZ17). GIW is supported by the Australian Research Council (ARC) (DP0772238). JCW is an ARC Federation Fellow and an honorary NHMRC Principal Research Fellow.