Journal article
Cascleave: Towards more accurate prediction of caspase substrate cleavage sites
J Song, H Tan, H Shen, K Mahmood, SE Boyd, GI Webb, T Akutsu, JC Whisstock
Bioinformatics | OXFORD UNIV PRESS | Published : 2010
Abstract
Motivation: The caspase family of cysteine proteases play essential roles in key biological processes such as programmed cell death, differentiation, proliferation, necrosis and inflammation. The complete repertoire of caspase substrates remains to be fully characterized. Accordingly, systematic computational screening studies of caspase substrate cleavage sites may provide insight into the substrate specificity of caspases and further facilitating the discovery of putative novel substrates. Results: In this article we develop an approach (termed Cascleave) to predict both classical (i.e. following a P1 Asp) and non-typical caspase cleavage sites. When using local sequence-derived profiles, ..
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Awarded by Australian Research Council
Funding Acknowledgements
J.S. would like to thank the National Health and Medical Research Council of Australia (NHMRC) and the Japan Society for the Promotion of Science (JSPS) for financially supporting this research via the NHMRC Peter Doherty and JSPS Postdoctoral Fellowships. H.S. was supported by the National Natural Science Foundation of China (60704047), Science and Technology Commission of Shanghai Municipality (08ZR1410600, 08JC1410600), and sponsored by Shanghai Pujiang Program and Innovation Program of Shanghai Municipal Education Commission (10ZZ17). G. I. W. is supported by the Australian Research Council (DP0772238). J C.W. is a NHMRC Principal Research Fellow and an ARC Federation Fellow.