Journal article
Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance
JWE Jocken, GH Goossens, H Boon, RR Mason, Y Essers, B Havekes, MJ Watt, LJ Van Loon, EE Blaak
Diabetologia | SPRINGER | Published : 2013
Abstract
Aims/hypothesis: Impaired regulation of lipolysis and accumulation of lipid intermediates may contribute to obesity-related insulin resistance and type 2 diabetes mellitus. We investigated insulin-mediated suppression of lipolysis in abdominal subcutaneous adipose tissue (AT) and skeletal muscle (SM) of obese men with normal glucose tolerance (NGT) and obese type 2 diabetic men. Methods: Eleven NGT men and nine long-term diagnosed type 2 diabetic men (7 ± 1 years), matched for age (58 ± 2 vs 62 ± 2 years), BMI (31.4 ± 0.6 vs 30.5 ± 0.6 kg/m2) and V × O 2 max (28.9 ± 1.5 vs 29.5 ± 2.4 ml kg-1 min-1) participated in this study. Interstitial glycerol concentrations in AT and SM were assessed us..
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Funding Acknowledgements
This work was supported by a VENI grant (016.116.074) from the Netherlands Organisation for Scientific Research (NWO) to JWEJ and a clinical research grant from the European Foundation for the Study of Diabetes (EFSD) to EEB and JWEJ. MJW is supported by research grants from the National Health and Medical Research Council of Australia.