Journal article

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning.

Alex Reichenbach, Romana Stark, Mathieu Mequinion, Raphael RG Denis, Jeferson F Goularte, Rachel E Clarke, Sarah H Lockie, Moyra B Lemus, Greg M Kowalski, Clinton R Bruce, Cheng Huang, Ralf B Schittenhelm, Randall L Mynatt, Brian J Oldfield, Matthew J Watt, Serge Luquet, Zane B Andrews

Cell Rep | Published : 2018

Abstract

AgRP neurons control peripheral substrate utilization and nutrient partitioning during conditions of energy deficit and nutrient replenishment, although the molecular mechanism is unknown. We examined whether carnitine acetyltransferase (Crat) in AgRP neurons affects peripheral nutrient partitioning. Crat deletion in AgRP neurons reduced food intake and feeding behavior and increased glycerol supply to the liver during fasting, as a gluconeogenic substrate, which was mediated by changes to sympathetic output and peripheral fatty acid metabolism in the liver. Crat deletion in AgRP neurons increased peripheral fatty acid substrate utilization and attenuated the switch to glucose utilization af..

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University of Melbourne Researchers