Journal article
Impact of endurance exercise training on adipocyte microRNA expression in overweight men
T Tsiloulis, J Pike, D Powell, FJ Rossello, BJ Canny, RCR Meex, MJ Watt
FASEB Journal | WILEY | Published : 2017
Abstract
Adipocytes are major regulators of metabolism, and endurance exercise training improves adipocyte function; however, the molecular mechanisms that regulate chronic adaptive responses remain unresolved. micro- RNAs (miRNAs) influence adipocyte differentiation and metabolism.Accordingly,we aimed to determinewhether adipocyte miRNA expression is responsive to exercise training and to identify exercise-responsive miRNAs that influence adipocyte metabolism. Next-generation sequencing was used to profile miRNA expression of adipocytes that were isolated from abdominal subcutaneous (ABD) and gluteofemoral (GF) adipose tissue of overweight men before and after 6wk of endurance exercise training.Diff..
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Grants
Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by NHMRC
Funding Acknowledgements
The authors thank Trevor Wilson (Monash Health Translation Precinct, Clayton, VIC, Australia) for technical assistance, Martin Dalton from Monash Sport for enabling access to the training facilities, and Aaron Russell (Deakin University, Burwood, VIC, Australia) for technical assistance. This work was supported by a research grant from the National Health and Medical Research Council (NHMRC) of Australia (ID: APP1098972). T.T. is supported by the Australian Postgraduate Award (Monash University) and the Paula and Jack Hansky Ph.D. Scholarship. M.J.W. is supported by a Senior Research Fellowship from the NHMRC (ID: APP1077703).