Association of Imaging Markers of Myocardial Fibrosis With Metabolic and Functional Disturbances in Early Diabetic Cardiomyopathy
Christine Jellis, Jeremy Wright, Dominic Kennedy, Julian Sacre, Carly Jenkins, Brian Haluska, Jennifer Martin, John Fenwick, Thomas H Marwick
Circulation: Cardiovascular Imaging | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011
BACKGROUND: Metabolic and vascular disturbances contribute to diabetic cardiomyopathy, but the role of interstitial fibrosis in early disease is unproven. We sought to assess the relationship between imaging markers of diffuse fibrosis and myocardial dysfunction and to link this to possible causes of early diabetic cardiomyopathy. METHODS AND RESULTS: Hemodynamic and metabolic data were measured in 67 subjects with type 2 diabetes mellitus (age 60±10 years) with no cardiac symptoms. Myocardial function was evaluated with standard echocardiography and myocardial deformation; ischemia was excluded by exercise echocardiography. Calibrated integrated backscatter was calculated from parasternal l..View full abstract
Awarded by National Health and Medical Research Council, Canberra, Australia
This study was supported in part by a Centres for Clinical Research Excellence award (455832) from the National Health and Medical Research Council, Canberra, Australia. Dr Jellis is supported by a Research Entry Scholarship from the Vincent Fairfax Family Foundation and the Royal Australasian College of Physicians. CMR scans were funded by the Gallipoli Foundation, Greenslopes Private Hospital, Brisbane, Australia, and performed at Queensland X-ray, Greenslopes Private Hospital, Brisbane, Australia. The prototype T1 mapping sequence and the Vizpack processing software were supplied by GE Healthcare for the purposes of this study. Procollagen biomarker assays were purchased with a CardioVascular Lipid grant from Pfizer Australia.