Journal article
Association of cardiac autonomic neuropathy with subclinical myocardial dysfunction in type 2 diabetes
JW Sacre, B Franjic, CL Jellis, C Jenkins, JS Coombes, TH Marwick
Jacc Cardiovascular Imaging | ELSEVIER SCIENCE INC | Published : 2010
Abstract
Objectives The purpose of this study was to investigate the independent association between global cardiac autonomic neuropathy (CAN) and left ventricular (LV) dysfunction in addition to regional associations of LV dysinnervation and function, in patients with type 2 diabetes mellitus (T2DM). Background CAN represents a potential mechanism in the etiology of nonischemic diabetic cardiomyopathy. Methods Clinical measures of CAN based on total spectral power of heart rate variability and cardiac reflex testing and echocardiographic assessment of LV function were performed in 118 patients with type 2 diabetes mellitus. Systolic and diastolic function were defined at rest and peak exercise using..
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Funding Acknowledgements
This work was supported in part by a Centre of Clinical Research Excellence award from the National Health and Medical Research Council, Canberra, Australia. The authors have reported that they have no relationships to disclose. Drs. Sacre and Franjic contributed equally to this work. Sherif Nagueh, MD, served as Guest Editor for this article.