Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia
Natalie J Hannan, Natalie K Binder, Sally Beard, Nguyen Tuong-Vi, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018
Preeclampsia is one of the most serious complications of pregnancy. Currently there are no medical treatments. Given placental oxidative stress may be an early trigger in the pathogenesis of preeclampsia, therapies that enhance antioxidant pathways have been proposed as treatments. Melatonin is a direct free-radical scavenger and indirect antioxidant. We performed in vitro assays to assess whether melatonin 1) enhances the antioxidant response element genes (heme-oxygenase 1, (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), thioredoxin (TXN)) or 2) alters secretion of the anti-angiogenic factors soluble fms-like tyrosine kinase-1 (sFLT) or soluble e..View full abstract
Related Projects (2)
Awarded by National Health and Medical Research Council of Australia (NHMRC)
The National Health and Medical Research Council of Australia (NHMRC) provided salary support (#1050765 to ST; #1062418 to TKL). NJH salary was supported by a University of Melbourne CR Roper Fellowship. The funders had no role in study design, data collection, analysis or decision to publish.